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Kumki Movie Free Downloading Tamil Thiruttu Vcd Com


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Thiruttuvcd tamil movies free download Kumki movie free download; Kumki tamil movie free downloading tamil thiruttu vcd com;.miR-362-5p inhibits malignant phenotypes of human prostate cancer cells by targeting AKT1.
MicroRNAs (miRNAs) are an extensive class of small non-coding RNAs that have been reported to play a crucial role in cancer malignancy. In our previous work, we found that miR-362-5p was down-regulated in human prostate cancer cell lines, DU145 and PC3. Moreover, there was a positive correlation between miR-362-5p expression and favorable prognosis in human prostate cancer patients. In this study, we further determined the biological function of miR-362-5p in human prostate cancer cells. Our data found that enforced expression of miR-362-5p inhibited prostate cancer cell growth, induced cell-cycle arrest and apoptosis in prostate cancer cells, and induced strong suppression of AKT1 at the protein level. The expression levels of p27 and p21, which were the primary targets of AKT1, were also down-regulated upon overexpression of miR-362-5p. Furthermore, we identified the AKT1 3'-UTR as a bona fide target of miR-362-5p in the regulation of prostate cancer cell growth, and we then verified that miR-362-5p functions as a tumor suppressor miRNA in human prostate cancer by directly targeting AKT1. Taken together, our results may provide novel insights into the application of miR-362-5p in the diagnosis and therapy of human prostate cancer.Diversity of corticospinal projections to the striatum and the cerebellum in the rhesus monkey (Macaca mulatta).
The distribution of corticospinal projections to the cerebellum, the striatum, and the red nucleus was determined in the rhesus monkey by using
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