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New Technology to Promote Drug Development-AI Technology

For a long time, the research and development of each new drug has faced the challenges of high cost and long cycle. In response to these challenges, major pharmaceutical companies have shifted from targeting common diseases to developing drugs for specific diseases. At the same time, these companie...

Liposomes in Anti-tumour Drug Carriers

IntroductionChemotherapy with anti-tumor agents is currently one of the most important systemic treatments for cancer. However, direct treatment with drugs lacks specificity and sensitivity and tends to attack normal cells indiscriminately, resulting in side effects. Liposomes, as drug carriers, pro...

An Overview of Isotopes

What are Isotopes?Isotopes are different atoms of the same element with the same number of protons and different numbers of neutrons called isotopes of each other, which can also be interpreted as different nuclides of the same element called isotopes of each other. An isotope is one of two or more ...

Research Progress on Aluminum Adjuvants and Their Mechanisms of Action

What are Adjuvants?Adjuvants, also known as immunomodulators or immune enhancers, are an additive to vaccines. Adjuvants are non-specific immune enhancers that enhance or alter the type of immune response to an antigen. Adjuvants can help antigens induce long-term effective specific immune resp...

Fermentation CDMO: Microbial Production of Ergothioneine

What is Ergothioneine?Ergothioneine is a natural product found widely in various organisms, especially in ergot, where it is present in higher amounts. At physiological pH, ergothioneine is stable since it mainly exists in the form of thione. It possesses various physiological functions, including s...

The Liposome-Based PROTAC Strategy

Proteolysis Targeting Chimeras (PROTACs) are a novel approach for degrading target proteins. Recently, a new split-and-mix PROTAC (SM-PROTAC) system based on liposome self-assembly, known as LipoSM-PROTAC, was reported in the Journal of the American Chemical Society. The LipoSM-PROTAC system ex...

Unveiling the Secrets of Plant Power: A Deep Dive into Plant Vitamin Analysis

Plants, the silent heroes of our planet, are not just culinary delights or decorative ornaments. They are nature's chemical factories, churning out a vast array of bioactive compounds, including essential vitamins. Understanding the vitamin content of plants is crucial not only for human health ...

Lifeasible Simplifies Gene Editing with CRISPR Mutation Library Construction Services

Lifeasible, a leading provider of custom gene editing solutions, today announced the availability of its CRISPR Mutation Library construction services. This new offering empowers researchers to rapidly and efficiently generate large collections of targeted mutations in plants, accelerating the d...

Cyclic Peptide Synthesis Strategies in Drug Development

Compared to linear peptides, cyclic peptides exhibit excellent biocompatibility and chemical diversity, making them effective in overcoming limitations and playing a crucial role in new drug development. In recent years, there have been significant advances in cyclic peptide synthesis strategies and...

Do Peptide Drugs Need Acylation Blocking at Nα?

The formation of 2,5-diketopiperazine (DKP) with a bicyclic structure is one of the most detrimental side reactions and degradation pathways affecting peptide synthesis. Despite its crucial role as a versatile building block in drug discovery, the formation of DKP reactions is hi...