* _**Windows users:**_ Adobe Photoshop is a Windows program and requires a Windows operating system. You'll need the Windows Installer to install the program.
* _**Mac users:**_ Macintosh users who have an Intel processor should download the Intel-based version of Photoshop. If you have an Intel or Power PC processor, you can download the Macintosh version of Photoshop.
* _**Linux users:**_ Linux users can download the version of Photoshop native to their operating system.

You can purchase Photoshop as a stand-alone image editing and compositing program, or you can buy Adobe's Creative Suite, which includes Photoshop and other programs in one package.

It is still a very powerful tool when used to its full potential. But, it is not as good at creating images as Photoshop.

Learn Adobe Photoshop Elements fast with these tips, tricks and tutorials.

Most Photoshop Elements Features You’ll Need to Know to Create Great Images

Here are the most important features you should know about before you start using Photoshop Elements:

1. Levels

Quick tip: click on the crop tool, then draw a box around the area that you want.

2. Curves

You can use the Curves tool to adjust contrast, brightness and color.

3. Color tools

Click on a color to change its color. This will open the tool and allow you to change the color.

4. Photo effects

Click on an effect and follow the prompts to apply it to the image.

5. Adjustments

Click on an adjustment and follow the prompts to apply it to the image.

6. Free transform

Click on a tool to apply a transform to the image.

7. Open a template

Open a template and use it to copy and paste the content of the template to the image.

8. Masking

Click on the masking tool and use the mask to add, delete or change the brightness of the part of the image that you mask.

9. Raster Effects

Click on the raster effects tool and follow the prompts to apply the effect to the image.

10. Type tools

Click on a tool and follow the prompts to use a tool of type.

11. Clipping masks

Use the clipping masks tool to add a shape to the image.

12. Object-based filters

Use the filter engine to change the image using one or more filters.

13. Masking

Click on the masking tool and follow the prompts to apply a mask.

14. Pixel filter

Use this filter to change the brightness of the whole or parts of the image.

15. Define custom brushes

Click on the brushes tool and choose a custom brush.

16. Stylize

Click on the stylize tool and follow the prompts to apply a style to the image.

17. Interactive tools

Use the interactive tools to move, rotate, resize and add text to the image.
05a79cecff

---
title: "PoI"
date: 2018-04-23 13:09:00
author: Jeff Arnett
image: tip-poi.png
tags:
- social
description: Tips and tricks for finding and tracking PoIs.
---

The first step in any digital forensics investigation is to determine if a computer is running (or has been running) an OS other than Microsoft's Windows.

* Windows machines are the most common suspects.
* OSX or macOS, while used at some point in the history of a computer, are generally not used anymore.
* Linux is an OS, but the majority of computer owners don't recognize it, and won't know how to look for it.
* Chromebooks are increasingly popular.

For those of you who are not aware, a _hacker_ is someone who seeks to perform unauthorized intrusions into a computer or other security instrument that is connected to the Internet.

Mammalian kinetochores are microtubule-based protein assemblies that serve as the primary spatial and functional regulators of chromosome segregation during mitosis and meiosis. The Ndc80/Sfi1/hSpindly complex is a critical microtubule-binding unit within the inner kinetochore. We have shown that the hSpindly subunit, a seven-pass transmembrane protein containing three Src homology 3 (SH3) domains, binds to kinetochores and is required for formation of the Ndc80/Sfi1/hSpindly complex. hSpindly is also required for efficient recruitment of the outer kinetochore proteins KNL-1, CENP-T, CENP-C, and Aurora B, and for proper microtubule attachment to the kinetochore. The three-dimensional structure of the hSpindly SH3 domains, combined with structure-function analyses, has provided new insight into the role of hSpindly within the kinetochore. We have also shown that the hSpindly SH3 domains, via the interaction with the kinetochore, are responsible for recruitment of hSpindly to kinetochores. As in other protein-protein interaction systems, the residues of hSpindly that contact the residues of the kinetochore determine where the hSpindly SH3 domains are localized. Thus, there are two independent signals for the hSpindly localization to the kinetochore. A large number of kinetochore proteins interact with hSpindly, including Ndc80, hBubR1, and KNL-1. hSpindly, through its SH3 domains, recognizes many kinetochore proteins, including the Ndc80/hBubR1/KNL-1 complex. The Ndc80/hBubR1/KNL-1 complex is thought to be important in stabilizing the correct binding of microtubules to the kinetochore. Although the Ndc80/hBubR1/KNL-1 complex is likely to be one of the primary downstream factors of hSpindly, our preliminary data indicates that hSpindly is also required for binding of the Ndc80/hBubR1/KNL-1 complex to microtubules. The mechanism underlying the Ndc80/hBubR1/KN

Processor: 1.8 GHz Dual-Core Processor (RAM: 1 GB)
OS: Windows 7/8/10 (64-bit)
OS: Windows 10 (64-bit)
Hard Drive: 4 GB
Graphics: DirectX 9 Compatible Graphics Card with at least 1 GB of RAM
DirectX: Version 9.0c
Video: 1024x768 display resolution (or higher)
Input Device: Keyboard (Windows: USB Keyboards)
Network: Broadband Internet connection
Media: 7.1

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